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XB-ART-36289
J Steroid Biochem Mol Biol November 1, 2007; 107 (3-5): 149-55.
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Analysis of the p450 aromatase gene expression in the Xenopus brain and gonad.

Iwabuchi J , Wako S , Tanaka T , Ishikawa A , Yoshida Y , Miyata S .


Abstract
Analysis of 5''-RACE clones revealed two Cyp19 transcript variants (gonad p450 aroms 1 and 2) in the gonads and one Cyp transcript (brain p450 arom) in the brain that differed in their 5''-untranslated region (UTR). Since all cDNAs contained an identical open reading frame, it is considered that while Xenopus aromatase may be encoded by a single Cyp19 gene, it is transcribed by tissue-specific promoters, each of which may be regulated by a distinct set of transcriptional factors. While gonad p450 aroms 1 and 2 and brain p450 arom were expressed in the gonads, brain p450 arom was the predominantly expressed aromatase gene in the brain, with a low expression level of gonad p450 arom 1.

PubMed ID: 17669643
Article link: J Steroid Biochem Mol Biol


Species referenced: Xenopus
Genes referenced: cyp19a1 cyp26a1