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Dev Dyn May 1, 2004; 230 (1): 79-90.
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XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus.

Michiue T , Fukui A , Yukita A , Sakurai K , Danno H , Kikuchi A , Asashima M .

Wnt signaling pathways are involved during various stages in the development of many species. In Xenopus, the accumulation of beta-catenin on the dorsal side of embryo is required for induction of the organizer, while the head structure formation requires inhibition of Wnt signaling. Here, we report a role for xIdax, a negative regulator of Wnt signaling. XIdax is expressed in neural tissues at the neurula stage, and in the restricted region of the tadpole brain. Ectopic expression of xIdax inhibits the target gene expression, suggesting that xIdax can inhibit canonical Wnt signaling. To examine the function of xIdax, a morpholino oligo for xIdax (xIdaxMO) was designed. An injection into an animal pole cell caused a loss of forebrain. The anterior neural marker expression is decreased in xIdaxMO-injected embryo, suggesting that xIdax is required for anterior neural development. Moreover, a negative regulator that acts downstream of xIdax rescued this defect. We propose that Idax functions are dependent on the canonical Wnt pathway and are crucial for the anterior neural development.

PubMed ID: 15108311
Article link: Dev Dyn

Species referenced: Xenopus
Genes referenced: cer1 chdh chrd.1 cxxc4 dvl2 egr2 en2 gal.2 gsk3b hoxb9 ncam1 odc1 otx2 rax sox2
Morpholinos: cxxc4 MO1

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