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J Gen Physiol August 1, 2007; 130 (2): 217-21.
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Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH.

Tseng PY , Bennetts B , Chen TY .

The CLC-1 Cl(-) channel is abundantly expressed on the plasma membrane of muscle cells, and the membrane potential of muscle cells is largely controlled by the activity of this Cl(-) channel. Previous studies showed that low intracellular pH increases the overall open probability of recombinant CLC-1 channels in various expression systems. Low intracellular pH, however, is known to inhibit the Cl(-) conductance on the native muscle membrane, contradicting the findings from the recombinant CLC-1 channels in expressed systems. Here we show that in the presence of physiological concentrations of ATP, reduction of the intracellular pH indeed inhibits the expressed CLC-1, mostly by decreasing the open probability of the common gate of the channel.

PubMed ID: 17664348
PMC ID: PMC2151639
Article link: J Gen Physiol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: clcn1 pof1b

Article Images: [+] show captions
References [+] :
Accardi, Fast and slow gating relaxations in the muscle chloride channel CLC-1. 2000, Pubmed, Xenbase