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XB-ART-37000
Bioorg Med Chem Lett 2007 Sep 01;1717:4934-7. doi: 10.1016/j.bmcl.2007.06.021.
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Interaction of O-(undec-10-en)-yl-D-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT).

Ionita M , Krishna S , Léo PM , Morin C , Patel AP .


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All-O-undec-en-10-yl derivatives of d-glucose have been prepared and their affinities for the Plasmodium falciparum hexose transporter (PfHT) determined; the O-2 derivative displays a good apparent affinity for PfHT (K(I)=2 microM) with no significant interaction with the mammalian transporter GLUT1. This selectivity points to position -2 of glucose as an appropriate substitution site for the development of inhibitors of P. falciparum glucose uptake.

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Species referenced: Xenopus laevis
Genes referenced: slc2a1