XB-ART-37000
Bioorg Med Chem Lett
2007 Sep 01;1717:4934-7. doi: 10.1016/j.bmcl.2007.06.021.
Show Gene links
Show Anatomy links
Interaction of O-(undec-10-en)-yl-D-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT).
???displayArticle.abstract???
All-O-undec-en-10-yl derivatives of d-glucose have been prepared and their affinities for the Plasmodium falciparum hexose transporter (PfHT) determined; the O-2 derivative displays a good apparent affinity for PfHT (K(I)=2 microM) with no significant interaction with the mammalian transporter GLUT1. This selectivity points to position -2 of glucose as an appropriate substitution site for the development of inhibitors of P. falciparum glucose uptake.
???displayArticle.pubmedLink??? 17587575
???displayArticle.link??? Bioorg Med Chem Lett
Species referenced: Xenopus laevis
Genes referenced: slc2a1