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???displayArticle.abstract??? XMAP215 is a microtubule plus-end binding protein implicated in modulating microtubule dynamics. In this issue, Brouhard et al. (2008) propose a new mechanism to explain how XMAP215 promotes microtubule growth. They report that XMAP215 moves with the growing microtubule plus ends where it catalyzes the addition of tubulin subunits.
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Stu2p binds tubulin and undergoes an open-to-closed conformational change.
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Bieling,
Reconstitution of a microtubule plus-end tracking system in vitro.
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XMAP215 is a processive microtubule polymerase.
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Xenbase
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