Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-3874
J Neurobiol 2004 Apr 01;591:24-33. doi: 10.1002/neu.10337.
Show Gene links Show Anatomy links

Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development.

Fujisawa H .


???displayArticle.abstract???
The semaphorin receptors neuropilin and plexin were initially identified as antigens for monoclonal antibodies MAb-A5 and MAb-B2, which bind to specific neuropiles and plexiform layers within the Xenopus tadpole nervous systems, several years before the discovery of the first semaphorin. This article provides an overview of how neuropilin and plexin were discovered. In addition, it describes the functions of neuropilin in the signaling of chemorepulsive activities of class 3 semaphorins and roles of neuropilin-mediated semaphorin activities in the directional guidance of the peripheral nervous system (PNS) and integration of the peripheral ganglia.

???displayArticle.pubmedLink??? 15007824
???displayArticle.link??? J Neurobiol


Species referenced: Xenopus
Genes referenced: nrp1
???displayArticle.antibodies??? Nrp1 Ab1 Plxna1 Ab1