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Int J Dev Biol January 1, 2008; 52 (8): 1099-103.
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Dicer inactivation causes heterochronic retinogenesis in Xenopus laevis.

Decembrini S , Andreazzoli M , Barsacchi G , Cremisi F .

Maturation of miRNAs by dicer is required in vertebrates for normal neural development. Here we report that dicer inactivation in Xenopus affects cell cycle progression, survival and timing of the generation of retinal cells, resulting in small retinas with lamination defects. In particular, dicer inactivation delays the exit from the cell cycle and the translation of key genes of late neurogenesis, highlighting a crucial role of miRNAs in retinal development.

PubMed ID: 18956342
Article link: Int J Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: crx dicer1 gal.2 mmut mos otx2 prox1 rbp3 rbpms2 sult2a1 tbx2 utp25
Morpholinos: dicer1 MO1 dicer1 MO2

Article Images: [+] show captions