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Development November 1, 2008; 135 (22): 3719-29.
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Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation.

Wnt signaling in development and adult tissue homeostasis requires tight regulation to prevent patterning abnormalities and tumor formation. Here, we show that the maternal Wnt antagonist Dkk1 downregulates both the canonical and non-canonical signaling that are required for the correct establishment of the axes of the Xenopus embryo. We find that the target Wnts of Dkk activity are maternal Wnt5a and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling. We determine that Wnt5a and Wnt11 form a previously unrecognized complex. This work suggests a new aspect of Wnt signaling: two Wnts acting in a complex together to regulate embryonic patterning.

PubMed ID: 18927149
Article link: Development

Species referenced: Xenopus laevis
Genes referenced: chrd.1 ctnnb1 dkk1 nodal3.1 nodal3.2 nodal5 nodal5.2 nodal5.4 smad1 smad2 wnt11 wnt11b wnt5a
Morpholinos: ctnnb1 MO1

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