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XB-ART-38841
Dev Dyn November 1, 2008; 237 (11): 3352-60.
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Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal development.

Bury FJ , Moers V , Yan J , Souopgui J , Quan XJ , De Geest N , Kricha S , Hassan BA , Bellefroid EJ .


Abstract
BBP proteins constitute a subclass of CUL3 interacting BTB proteins whose in vivo function remains unknown. Here, we show that the Xenopus BBP gene BTBD6 and the single Drosophila homologue of mammalian BBP genes lute are strongly expressed in the developing nervous system. In Xenopus, BTBD6 expression responds positively to proneural and negatively to neurogenic gene overexpression. Knockdown of BTBD6 in Xenopus or loss of Drosophila lute result in embryos with strong defects in late neuronal markers and strongly reduced and disorganized axons while early neural development is unaffected. XBTBD6 knockdown in Xenopus also affects muscle development. Together, these data indicate that BTBD6/lute is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development.

PubMed ID: 18855900
Article link: Dev Dyn


Species referenced: Xenopus laevis
Genes referenced: actc1 actl6a b3gat1l btbd6 cul3 dll1 elavl3 krt12.4 myod1 neurod1 neurog2 notch1 nucb1 sox3 tbxt tmem158 tubb2b


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