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J Am Soc Nephrol
2009 Jan 01;201:48-56. doi: 10.1681/ASN.2008040345.
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Increased expression of secreted frizzled-related protein 4 in polycystic kidneys.
Romaker D
,
Puetz M
,
Teschner S
,
Donauer J
,
Geyer M
,
Gerke P
,
Rumberger B
,
Dworniczak B
,
Pennekamp P
,
Buchholz B
,
Neumann HP
,
Kumar R
,
Gloy J
,
Eckardt KU
,
Walz G
.
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Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disease associated with progressive renal failure. Although cyst growth and compression of surrounding tissue may account for some loss of renal tissue, the other factors contributing to the progressive renal failure in patients with ADPKD are incompletely understood. Here, we report that secreted frizzled-related protein 4 (sFRP4) is upregulated in human ADPKD and in four different animal models of PKD, suggesting that sFRP4 expression is triggered by a common mechanism that underlies cyst formation. Cyst fluid from ADPKD kidneys activated the sFRP4 promoter and induced production of sFRP4 protein in renal tubular epithelial cell lines. Antagonism of the vasopressin 2 receptor blocked both promoter activity and tubular sFRP4 expression. In addition, sFRP4 selectively influenced members of the canonical Wnt signaling cascade and promoted cystogenesis of the zebrafish pronephros. sFRP4 was detected in the urine of both patients and animals with PKD, suggesting that sFRP4 may be a potential biomarker for monitoring the progression of ADPKD. Taken together, these observations suggest a potential role for SFRP4 in the pathogenesis of ADPKD.
Abu-Jawdeh,
Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy.
1999, Pubmed,
Xenbase
Abu-Jawdeh,
Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy.
1999,
Pubmed
,
Xenbase
Adachi,
The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins.
2006,
Pubmed
Bafico,
Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.
1999,
Pubmed
,
Xenbase
Barandon,
Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA.
2003,
Pubmed
Benzing,
Wnt signaling in polycystic kidney disease.
2007,
Pubmed
Berndt,
Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.
2003,
Pubmed
Bodine,
The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis.
2005,
Pubmed
Corbit,
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.
2008,
Pubmed
Dennis,
A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling.
1999,
Pubmed
Donauer,
Expression profiling on chronically rejected transplant kidneys.
2003,
Pubmed
Drake,
The role of sFRP4, a secreted frizzled-related protein, in ovulation.
2003,
Pubmed
Drummond,
Kidney development and disease in the zebrafish.
2005,
Pubmed
Dufourcq,
FrzA, a secreted frizzled related protein, induced angiogenic response.
2002,
Pubmed
Ellies,
The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain.
2000,
Pubmed
Fliegauf,
When cilia go bad: cilia defects and ciliopathies.
2007,
Pubmed
Fu,
The subcellular localization of TRPP2 modulates its function.
2008,
Pubmed
Gattone,
Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist.
2003,
Pubmed
Gerdes,
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.
2007,
Pubmed
Grantham,
In vitro fluid secretion by epithelium from polycystic kidneys.
1995,
Pubmed
Grantham,
The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances.
1996,
Pubmed
He,
Suppressing Wnt signaling by the hedgehog pathway through sFRP-1.
2006,
Pubmed
,
Xenbase
Jones,
Modulated expression of secreted frizzled-related proteins in human retinal degeneration.
2000,
Pubmed
Jones,
Secreted Frizzled-related proteins: searching for relationships and patterns.
2002,
Pubmed
Kawano,
Secreted antagonists of the Wnt signalling pathway.
2003,
Pubmed
,
Xenbase
Ko,
Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer.
2002,
Pubmed
Lacher,
Role of DDC-4/sFRP-4, a secreted frizzled-related protein, at the onset of apoptosis in mammary involution.
2003,
Pubmed
Lee,
Expression of secreted frizzled-related protein 2 in a primary canine mammary tumor cell line: a candidate tumor marker for mammary tumor cells.
2003,
Pubmed
Lee,
Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands.
2004,
Pubmed
Lee,
Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma.
2004,
Pubmed
Lee,
Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases.
2006,
Pubmed
,
Xenbase
Olbrich,
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis.
2003,
Pubmed
Pennekamp,
The ion channel polycystin-2 is required for left-right axis determination in mice.
2002,
Pubmed
Perner,
The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros.
2007,
Pubmed
Piontek,
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.
2007,
Pubmed
Qian,
Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.
2005,
Pubmed
Saadi-Kheddouci,
Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene.
2001,
Pubmed
Schieren,
Gene profiling of polycystic kidneys.
2006,
Pubmed
Schneider,
Calcium fluxes in dorsal forerunner cells antagonize beta-catenin and alter left-right patterning.
2008,
Pubmed
,
Xenbase
Schumann,
Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression.
2000,
Pubmed
Simons,
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.
2005,
Pubmed
,
Xenbase
Sun,
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.
2004,
Pubmed
,
Xenbase
Suzuki,
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
2004,
Pubmed
Torres,
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease.
2004,
Pubmed
Urakami,
Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA.
2006,
Pubmed
Wilson,
Polycystic kidney disease.
2004,
Pubmed
Wilson,
Epithelial cell polarity and disease.
1997,
Pubmed
Wong,
Cloning and characterization of the promoter region of the mouse frizzled-related protein 4 gene.
2003,
Pubmed
Woo,
Apoptosis and loss of renal tissue in polycystic kidney diseases.
1995,
Pubmed
Yam,
Transcriptional activity of the promoter region of rat frizzled-related protein gene.
2001,
Pubmed
Yamaguchi,
Cyst fluid from a murine model of polycystic kidney disease stimulates fluid secretion, cyclic adenosine monophosphate accumulation, and cell proliferation by Madin-Darby canine kidney cells in vitro.
1995,
Pubmed
Yoshino,
Secreted Frizzled-related proteins can regulate metanephric development.
2001,
Pubmed
Zhou,
Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors.
1998,
Pubmed
