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Genes Dev June 15, 2009; 23 (12): 1393-8.

Cadherin-11 regulates protrusive activity in Xenopus cranial neural crest cells upstream of Trio and the small GTPases.

Xenopus Cadherin-11 (Xcad-11) is expressed when cranial neural crest cells (CNC) acquire motility. However, its function in stimulating cell migration is poorly understood. Here, we demonstrate that Xcad-11 initiates filopodia and lamellipodia formation, which is essential for CNC to populate pharyngeal pouches. We identified the cytoplasmic tail of Xcad-11 as both necessary and sufficient for proper CNC migration as long as it was linked to the plasma membrane. Our results showing that guanine nucleotide exchange factor (GEF)-Trio binds to Xcad-11 and can functionally substitute for it like constitutively active forms of RhoA, Rac, and cdc42 unravel a novel cadherin function.

PubMed ID: 19528317
PMC ID: PMC2701577
Article link: Genes Dev
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: akt1 cad cald1 cat.2 cdc42 cdh11 cdh3 cdh6 ctnnd1 rac1 rhoa twist1
Morpholinos: cdh11 MO1 cdh11 MO2

Article Images: [+] show captions
References [+] :
Alfandari, Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration. 2001, Pubmed, Xenbase