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XB-ART-40065
Dev Dyn August 1, 2009; 238 (8): 2044-57.
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Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution.

Gray RS , Bayly RD , Green SA , Agarwala S , Lowe CJ , Wallingford JB .


Abstract
Dishevelled (Dvl) proteins are key transducers of Wnt signaling encoded by members of a multi-gene family in vertebrates. We report here the divergent, tissue-specific expression patterns for all three Dvl genes in Xenopus embryos, which contrast dramatically with their expression patterns in mice. Moreover, we find that the expression patterns of Dvl genes in the chick diverge significantly from those of Xenopus. In addition, in hemichordates, an outgroup to chordates, we find that the one Dvl gene is dynamically expressed in a tissue-specific manner. Using knockdowns, we find that Dvl1 and Dvl2 are required for early neural crest specification and for somite segmentation in Xenopus. Most strikingly, we report a novel role for Dvl3 in the maintenance of gene expression in muscle and in the development of the Xenopus sclerotome. These data demonstrate that the expression patterns and developmental functions of specific Dvl genes have diverged significantly during chordate evolution.

PubMed ID: 19618470
PMC ID: PMC2782374
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: dvl1 dvl2 dvl3 fn1 myf5 myod1 pax1 snai2 tcf15 twist1
Antibodies: Somite Ab1
Morpholinos: dvl1 MO1 dvl2 MO1 dvl3 MO1 dvl3 MO2


Article Images: [+] show captions
References [+] :
Afonin, Cell behaviors associated with somite segmentation and rotation in Xenopus laevis. 2006, Pubmed, Xenbase