Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-40321
Dev Dyn November 1, 2009; 238 (11): 2891-902.
Show Gene links Show Anatomy links

Cloning and characterization of voltage-gated calcium channel alpha1 subunits in Xenopus laevis during development.

Lewis BB , Wester MR , Miller LE , Nagarkar MD , Johnson MB , Saha MS .


Abstract
Voltage-gated calcium channels play a critical role in regulating the Ca2+ activity that mediates many aspects of neural development, including neural induction, neurotransmitter phenotype specification, and neurite outgrowth. Using Xenopus laevis embryos, we describe the spatial and temporal expression patterns during development of the 10 pore-forming alpha1 subunits that define the channels'' kinetic properties. In situ hybridization indicates that CaV1.2, CaV2.1, CaV2.2, and CaV3.2 are expressed during neurula stages throughout the neural tube. These, along with CaV1.3 and CaV2.3, beginning at early tail bud stages, and CaV3.1 at late tail bud stages, are detected in complex patterns within the brain and spinal cord through swimming tadpole stages. Additional expression of various alpha1 subunits was observed in the cranial ganglia, retina, olfactory epithelium, pineal gland, and heart. The unique expression patterns for the different alpha1 subunits suggests they are under precise spatial and temporal regulation and are serving specific functions during embryonic development.

PubMed ID: 19795515
PMC ID: PMC6697093
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cacna1a cacna1b cacna1c cacna1d cacna1e cacna1f cacna1g cacna1h cacna1s cacnb3 cav1 cav2 cav3.1 cav3.2


Article Images: [+] show captions
References [+] :
Aguilar, N- and P/Q-type Ca2+ channels regulate synaptic efficacy between spinal dorsolateral funiculus terminals and motoneurons. 2004, Pubmed