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Dev Cell September 1, 2009; 17 (3): 301-3.
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The curious case of bivalent marks.

Herz HM , Nakanishi S , Shilatifard A .

Bivalently marked chromatin, containing both histone H3 lysine 4 (H3K4) and H3K27 trimethylation, is a hallmark of developmentally regulated paused promoters in mammalian embryonic stem cells. In this issue of Developmental Cell, Akkers et al. report that Xenopus tropicalis embryos transition through early development without the requirement for bivalently marked promoters.

PubMed ID: 19758552
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: tbx2

References :
Akkers, A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos. 2009, Pubmed, Xenbase