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XB-ART-40522
Dev Dyn December 1, 2009; 238 (12): 3185-92.

Characterization of the expression pattern of the PRC2 core subunit Suz12 during embryonic development of Xenopus laevis.



Abstract
The Polycomb repressive complex 2 is a multimeric aggregate that mediates silencing of a broad range of genes, and is associated with important biological contexts such as stem cell maintenance and cancer progression. PRC2 mainly trimethylates lysine 27 of histone H3 and is composed of three essential core subunits: EZH2, EED, and SUZ12. The Xenopus orthologs of PRC2 subunits Ezh2 and Eed have been described but Suz12 remained unidentified. Here, we report the cloning of the Xenopus Suz12, and determine its spatiotemporal expression during development. Xsuz12 transcript is provided maternally and continues to be expressed throughout development, particularly in the anterior part of the developing central nervous system. Importantly, comparative analysis of the expression of the PRC2 subunits Xez, Xeed, and Xrbbp4 indicates that their expression largely coincides with Xsuz12 in the nervous system, suggesting that PRC2 may have unexplored functions in the development of the frog central nervous system.

PubMed ID: 19877271
PMC ID: PMC3360962
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: eed ezh2 rbbp4 suz12


Article Images: [+] show captions
References [+] :
Barnett, Xenopus Enhancer of Zeste (XEZ); an anteriorly restricted polycomb gene with a role in neural patterning. 2001, Pubmed, Xenbase