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Dev Biol February 15, 2010; 338 (2): 117-26.

Gene switching at Xenopus laevis metamorphosis.

Mukhi S , Cai L , Brown DD .

During the climax of amphibian metamorphosis many tadpole organs remodel. The different remodeling strategies are controlled by thyroid hormone (TH). The liver, skin, and tail fibroblasts shut off tadpole genes and activate frog genes in the same cell without DNA replication. We refer to this as "gene switching". In contrast, the exocrine pancreas and the intestinal epithelium dedifferentiate to a progenitor state and then redifferentiate to the adult cell type. Tadpole and adult globin are not present in the same cell. Switching from red cells containing tadpole-specific globin to those with frog globin in the liver occurs at a progenitor cell stage of development and is preceded by DNA replication. Red cell switching is the only one of these remodeling strategies that resembles a stem cell mechanism.

PubMed ID: 19896938
Article link: Dev Biol

Species referenced: Xenopus
Genes referenced: adh1c alb cdh1 col11a1 cps1 cyp4b1 fabp1 fetub hbg2 hrg krt62 krt78.6 mmp13 mmp13l trdn

GEO Series: GSE16017: NCBI
GSE16018: NCBI
GSE16074: NCBI
GSE16075: NCBI

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