Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-40891
Biol Pharm Bull 2010 Jan 01;331:138-41. doi: 10.1248/bpb.33.138.
Show Gene links Show Anatomy links

Effect of NIP-142 on potassium channel alpha-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization.

Tanaka H , Namekata I , Hamaguchi S , Kawamura T , Masuda H , Tanaka Y , Iida-Tanaka N , Takahara A .


???displayArticle.abstract???
Effects of NIP-142, a benzopyran compound which terminates experimental atrial arrhythmia, on potassium channel alpha-subunits and mouse atrial repolarization were examined. NIP-142 concentration-dependently blocked the outward current through potassium channel alpha subunits Kv1.5, Kv4.2 and Kv4.3 expressed in Xenopus oocytes. In isolated mouse atrial myocardia, NIP-142 prolonged the action potential duration and effective refractory period, and increased the contractile force. These results suggest that NIP-142 blocks the potassium channels underlying the transient and sustained outward currents, which may contribute to its antiarrhythmic activity.

???displayArticle.pubmedLink??? 20045952
???displayArticle.link??? Biol Pharm Bull


Species referenced: Xenopus
Genes referenced: kcna5 kcnd2 kcnd3