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J Biol Chem October 1, 2010; 285 (40): 30814-24.

ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression.

Masserdotti G , Badaloni A , Green YS , Croci L , Barili V , Bergamini G , Vetter ML , Consalez GG .

Zinc finger protein 423 encodes a 30 Zn-finger transcription factor involved in cerebellar and olfactory development. ZFP423 is a known interactor of SMAD1-SMAD4 and of Collier/Olf-1/EBF proteins, and acts as a modifier of retinoic acid-induced differentiation. In the present article, we show that ZFP423 interacts with the Notch1 intracellular domain in mammalian cell lines and in Xenopus neurula embryos, to activate the expression of the Notch1 target Hes5/ESR1. This effect is antagonized by EBF transcription factors, both in cultured cells and in Xenopus embryos, and amplified in vitro by BMP4, suggesting that ZFP423 acts to integrate BMP and Notch signaling, selectively promoting their convergence onto the Hes5 gene promoter.

PubMed ID: 20547764
PMC ID: PMC2945575
Article link: J Biol Chem
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bmp4 ebf1 ebf2 ebf3 esr1 hes1 hes5.1 hes5.2 notch1 nrarp slc13a2 smad1 smad4 smad4.2 tbx2 znf423
Morpholinos: znf423 MO1

Article Images: [+] show captions
References [+] :
Alcaraz, Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. 2006, Pubmed