Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Biol Chem
2010 Jun 25;28526:19900-9. doi: 10.1074/jbc.M110.105312.
Show Gene links
Show Anatomy links
A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
Ramakrishnan L
,
Muller-Steffner H
,
Bosc C
,
Vacquier VD
,
Schuber F
,
Moutin MJ
,
Dale L
,
Patel S
.
???displayArticle.abstract???
Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate are ubiquitous calcium-mobilizing messengers produced by the same family of multifunctional enzymes, the ADP-ribosyl cyclases. Not all ADP-ribosyl cyclases have been identified, and how production of different messengers is achieved is incompletely understood. Here, we report the cloning and characterization of a novel ADP-ribosyl cyclase (SpARC4) from the sea urchin, a key model organism for the study of calcium-signaling pathways. Like several other members of the ADP-ribosyl cyclase superfamily, SpARC4 is a glycoprotein targeted to the plasma membrane via a glycosylphosphatidylinositol anchor. However, unlike most other members, SpARC4 shows a remarkable preference for producing cyclic ADP-ribose over nicotinic acid adenine dinucleotide phosphate. Mutation of a single residue (tyrosine 142) within a noncanonical active site reversed this striking preference. Our data highlight further diversification of this unusual enzyme family, provide mechanistic insight into multifunctionality, and suggest that different ADP-ribosyl cyclases are fine-tuned to produce specific calcium-mobilizing messengers.
Aarhus,
ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP.
1995, Pubmed
Aarhus,
ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP.
1995,
Pubmed
Berridge,
The versatility and universality of calcium signalling.
2000,
Pubmed
Berridge,
Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.
2002,
Pubmed
Bezin,
Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization.
2008,
Pubmed
Billington,
Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa.
2006,
Pubmed
Birsoy,
XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development.
2005,
Pubmed
,
Xenbase
Brailoiu,
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.
2009,
Pubmed
Brailoiu,
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles.
2010,
Pubmed
Bruzzone,
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells.
2003,
Pubmed
Cakir-Kiefer,
Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases.
2000,
Pubmed
Calcraft,
NAADP mobilizes calcium from acidic organelles through two-pore channels.
2009,
Pubmed
Ceni,
Evidence for an intracellular ADP-ribosyl cyclase/NAD+-glycohydrolase in brain from CD38-deficient mice.
2003,
Pubmed
Churamani,
Molecular characterization of a novel intracellular ADP-ribosyl cyclase.
2007,
Pubmed
,
Xenbase
Churamani,
Molecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.
2008,
Pubmed
,
Xenbase
Churchill,
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.
2002,
Pubmed
Clapper,
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.
1987,
Pubmed
Davis,
Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites.
2008,
Pubmed
De Flora,
Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system.
2004,
Pubmed
Fukushi,
Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca(2+) signaling using CD38 knockout mice.
2001,
Pubmed
Galione,
Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose.
1991,
Pubmed
Glick,
Primary structure of a molluscan egg-specific NADase, a second-messenger enzyme.
1991,
Pubmed
Goodrich,
Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni.
2005,
Pubmed
Graeff,
Enzymatic synthesis and characterizations of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity.
1994,
Pubmed
Graeff,
Cyclic GMP-dependent and -independent effects on the synthesis of the calcium messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
1998,
Pubmed
Graeff,
A single residue at the active site of CD38 determines its NAD cyclizing and hydrolyzing activities.
2001,
Pubmed
Graeff,
Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38.
2009,
Pubmed
Guse,
NAADP: a universal Ca2+ trigger.
2008,
Pubmed
Guse,
Second messenger signaling: multiple receptors for NAADP.
2009,
Pubmed
Guse,
Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose.
1999,
Pubmed
Hellmich,
Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme.
1991,
Pubmed
Hirata,
ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1.
1994,
Pubmed
Hohenegger,
Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor.
2002,
Pubmed
Howard,
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.
1993,
Pubmed
Jin,
CD38 is critical for social behaviour by regulating oxytocin secretion.
2007,
Pubmed
Kato,
CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion.
1999,
Pubmed
Kim,
CD38-mediated Ca2+ signaling contributes to angiotensin II-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation.
2010,
Pubmed
Kuhn,
Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.
2006,
Pubmed
Lange,
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.
2009,
Pubmed
Lee,
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose.
1995,
Pubmed
Lee,
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers.
2001,
Pubmed
Lee,
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
1999,
Pubmed
Lee,
ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite.
1991,
Pubmed
Leighton,
Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.
2003,
Pubmed
Liu,
Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
2006,
Pubmed
Matsumura,
Involvement of cytosolic NAD+ glycohydrolase in cyclic ADP-ribose metabolism.
1998,
Pubmed
Munshi,
Characterization of the active site of ADP-ribosyl cyclase.
1999,
Pubmed
Munshi,
Identification of the enzymatic active site of CD38 by site-directed mutagenesis.
2000,
Pubmed
Mészáros,
Sarcoplasmic reticulum-associated and protein kinase C-regulated ADP-ribosyl cyclase in cardiac muscle.
1997,
Pubmed
Nelsen,
Proprotein convertase genes in Xenopus development.
2005,
Pubmed
,
Xenbase
Partida-Sánchez,
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo.
2001,
Pubmed
Patel,
In with the TRP channels: intracellular functions for TRPM1 and TRPM2.
2009,
Pubmed
Patel,
Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.
2010,
Pubmed
Perraud,
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.
2001,
Pubmed
Prasad,
Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38.
1996,
Pubmed
Schuber,
Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites.
2004,
Pubmed
Soares,
NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells.
2007,
Pubmed
Sternfeld,
Hormonal control of ADP-ribosyl cyclase activity in pancreatic acinar cells from rats.
2003,
Pubmed
Tohgo,
Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.
1994,
Pubmed
Vasudevan,
Sperm express a Ca2+-regulated NAADP synthase.
2008,
Pubmed
Wilson,
Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction.
2001,
Pubmed
Xie,
ADP-ribosyl cyclase couples to cyclic AMP signaling in the cardiomyocytes.
2005,
Pubmed
Yamamoto-Katayama,
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.
2002,
Pubmed
Zhang,
Production of NAADP and its role in Ca2+ mobilization associated with lysosomes in coronary arterial myocytes.
2006,
Pubmed
Zhang,
Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase.
2007,
Pubmed
Zocchi,
NAD+-dependent internalization of the transmembrane glycoprotein CD38 in human Namalwa B cells.
1996,
Pubmed
