XB-ART-42102
Cold Spring Harb Perspect Biol
2009 Aug 01;12:a002881. doi: 10.1101/cshperspect.a002881.
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Wnt signaling from development to disease: insights from model systems.
Cadigan KM
,
Peifer M
.
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One of the early surprises in the study of cell adhesion was the discovery that beta-catenin plays dual roles, serving as an essential component of cadherin-based cell-cell adherens junctions and also serving as the key regulated effector of the Wnt signaling pathway. Here, we review our current model of Wnt signaling and discuss how recent work using model organisms has advanced our understanding of the roles Wnt signaling plays in both normal development and in disease. These data help flesh out the mechanisms of signaling from the membrane to the nucleus, revealing new protein players and providing novel information about known components of the pathway.
???displayArticle.pubmedLink??? 20066091
???displayArticle.pmcLink??? PMC2742092
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???displayArticle.grants??? [+]
R01 GM67236 NIGMS NIH HHS , R01 GM82994 NIGMS NIH HHS , R01 GM067236 NIGMS NIH HHS , R01 GM082994 NIGMS NIH HHS
GO keywords: Wnt signaling pathway
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