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XB-ART-4229
Proc Natl Acad Sci U S A January 6, 2004; 101 (1): 165-70.
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Thyroid hormone controls the development of connections between the spinal cord and limbs during Xenopus laevis metamorphosis.



Abstract
During premetamorphic stages, Xenopus laevis tadpoles expressing either a dominant-negative thyroid hormone (TH) receptor or a type-III iodothyronine deiodinase transgene in the nervous system have reduced TH-induced proliferation in the spinal cord and produce fewer hindlimb-innervating motorneurons. During prometamorphic stages, innervation of the hindlimbs is reduced, and few functional neuromuscular connections are formed. By metamorphic climax, limb movement is impaired, ranging from uncoordinated leg swimming to complete quadriplegia. This phenotype is due to transgene action in the tadpole spinal cord. The requirement of TH for neurogenesis during premetamorphosis is the earliest TH-regulated process reported to date in the sequence of metamorphic changes in anurans. The muscle formed during limb growth was previously shown to be a direct target of TH control. Here, we show that the same is true of the development of spinal cord cells that innervate the limbs.

PubMed ID: 14691251
PMC ID: PMC314156
Article link: Proc Natl Acad Sci U S A


Species referenced: Xenopus laevis
Genes referenced: aldh1a2 thibz trdn


Article Images: [+] show captions
References [+] :
Beach, Patterns of cell proliferation in the retina of the clawed frog during development. 1979, Pubmed, Xenbase