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XB-ART-42372
Dev Dyn December 1, 2010; 239 (12): 3446-66.

Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors.

Neilson KM , Pignoni F , Yan B , Moody SA .


Abstract
Six family transcription factors play important roles in craniofacial development. Their transcriptional activity can be modified by cofactor proteins. Two Six genes and one cofactor gene (Eya1) are involved in the human Branchio-otic (BO) and Branchio-otic-renal (BOR) syndromes. However, mutations in Six and Eya genes only account for approximately half of these patients. To discover potential new causative genes, we searched the Xenopus genome for orthologues of Drosophila cofactor proteins that interact with the fly Six-related factor, SO. We identified 33 Xenopus genes with high sequence identity to 20 of the 25 fly SO-interacting proteins. We provide the developmental expression patterns of the Xenopus orthologues for 11 of the fly genes, and demonstrate that all are expressed in developing craniofacial tissues with at least partial overlap with Six1/Six2. We speculate that these genes may function as Six-interacting partners with important roles in vertebrate craniofacial development and perhaps congenital syndromes.

PubMed ID: 21089078
PMC ID: PMC3059517
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus
Genes referenced: arhgef2 atp6v0d1 bop1 ccdc85c cdca8 cltc csnk2b ddx43 eya1 eya2 eya3 eya4 gadd45a gadd45g gba2 gnat1 hpf1 liph mcrs1 pa2g4 rps27 six1 six2 sobp tle1 tle2 tle4 tle5 tlx1 zmym2
GO keywords: neural crest cell development [+]

Disease Ontology terms: branchiootic syndrome
OMIMs: BRANCHIOOTORENAL SYNDROME 1; BOR1 [+]

Article Images: [+] show captions
References [+] :
Abdelhak, A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. 1997, Pubmed