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XB-ART-43044
Dev Neurobiol April 1, 2012; 72 (4): 585-99.

Imaging adhesion and signaling dynamics in Xenopus laevis growth cones.

Santiago-Medina M , Myers JP , Gomez TM .


Abstract
Xenopus laevis provides a robust model system to study cellular signaling and downstream processes during development both in vitro and in vivo. Intracellular signals must function within highly restricted spatial and temporal domains to activate specific downstream targets and cellular processes. Combining the versatility of developing Xenopus neurons with advances in fluorescent protein biosensors and imaging technologies has allowed many dynamic cellular processes to be visualized. This review will focus on the techniques we use to visualize and measure cell signaling, motility and adhesion by quantitative fluorescence microscopy in vitro and in vivo.

PubMed ID: 21465668
PMC ID: PMC3158960
Article link: Dev Neurobiol
Grant support: [+]

Species referenced: Xenopus laevis


Article Images: [+] show captions
References [+] :
Andersen, Live imaging of cell motility and actin cytoskeleton of individual neurons and neural crest cells in zebrafish embryos. 2010, Pubmed