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Nat Cell Biol
2011 Jun 01;136:676-85. doi: 10.1038/ncb2255.
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Semaphorin 3A induces CaV2.3 channel-dependent conversion of axons to dendrites.
Nishiyama M
,
Togashi K
,
von Schimmelmann MJ
,
Lim CS
,
Maeda S
,
Yamashita N
,
Goshima Y
,
Ishii S
,
Hong K
.
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Polarized neurites (axons and dendrites) form the functional circuitry of the nervous system. Secreted guidance cues often control the polarity of neuron migration and neurite outgrowth by regulating ion channels. Here, we show that secreted semaphorin 3A (Sema3A) induces the neurite identity of Xenopus spinal commissural interneurons (xSCINs) by activating Ca(V)2.3 channels (Ca(V)2.3). Sema3A treatment converted the identity of axons of cultured xSCINs to that of dendrites by recruiting functional Ca(V)2.3. Inhibition of Sema3A signalling prevented both the expression of Ca(V)2.3 and acquisition of the dendrite identity, and inhibition of Ca(V)2.3 function resulted in multiple axon-like neurites of xSCINs in the spinal cord. Furthermore, Sema3A-triggered cGMP production and PKG activity induced, respectively, the expression of functional Ca(V)2.3 and the dendrite identity. These results reveal a mechanism by which a guidance cue controls the identity of neurites during nervous system development.
Adler,
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation.
2006, Pubmed
Adler,
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation.
2006,
Pubmed
Arimura,
Neuronal polarity: from extracellular signals to intracellular mechanisms.
2007,
Pubmed
Barnes,
Establishment of axon-dendrite polarity in developing neurons.
2009,
Pubmed
Barnes,
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
2007,
Pubmed
Bradke,
Differentiated neurons retain the capacity to generate axons from dendrites.
2000,
Pubmed
Campbell,
Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.
2001,
Pubmed
,
Xenbase
Campbell,
Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones.
2003,
Pubmed
,
Xenbase
Craig,
Neuronal polarity.
1994,
Pubmed
Esch,
Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons.
1999,
Pubmed
Fenstermaker,
Regulation of dendritic length and branching by semaphorin 3A.
2004,
Pubmed
Gomis-Rüth,
Plasticity of polarization: changing dendrites into axons in neurons integrated in neuronal circuits.
2008,
Pubmed
Goshima,
A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse.
1997,
Pubmed
Gu,
Low-threshold Ca2+ current and its role in spontaneous elevations of intracellular Ca2+ in developing Xenopus neurons.
1993,
Pubmed
,
Xenbase
Guan,
Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2.
2007,
Pubmed
Henley,
Guiding neuronal growth cones using Ca2+ signals.
2004,
Pubmed
Hong,
Calcium signalling in the guidance of nerve growth by netrin-1.
2000,
Pubmed
,
Xenbase
Hong,
From guidance signals to movement: signaling molecules governing growth cone turning.
2010,
Pubmed
Jan,
The control of dendrite development.
2003,
Pubmed
Jiang,
Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators.
2005,
Pubmed
Jiménez-González,
Development of Ca2+-channel and BK-channel expression in embryos and larvae of Xenopus laevis.
2003,
Pubmed
,
Xenbase
Kaneko,
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord.
2006,
Pubmed
Li,
Calcium channels in Xenopus spinal neurons differ in somas and presynaptic terminals.
2001,
Pubmed
,
Xenbase
Li,
Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network.
2007,
Pubmed
,
Xenbase
Liu,
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.
2002,
Pubmed
Magee,
Characterization of single voltage-gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons.
1995,
Pubmed
Marín,
Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.
2001,
Pubmed
Moon,
Adjacent pioneer commissural interneuron growth cones switch from contact avoidance to axon fasciculation after midline crossing.
2005,
Pubmed
,
Xenbase
Morita,
Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.
2006,
Pubmed
Nishiyama,
Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning.
2003,
Pubmed
,
Xenbase
Nishiyama,
Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning.
2008,
Pubmed
,
Xenbase
Pham,
The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP.
2000,
Pubmed
Piper,
Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation.
2005,
Pubmed
,
Xenbase
Polleux,
Semaphorin 3A is a chemoattractant for cortical apical dendrites.
2000,
Pubmed
Poon,
UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.
2008,
Pubmed
Roberts,
The early development of neurons with GABA immunoreactivity in the CNS of Xenopus laevis embryos.
1987,
Pubmed
,
Xenbase
Roberts,
Development and characterization of commissural interneurones in the spinal cord of Xenopus laevis embryos revealed by antibodies to glycine.
1988,
Pubmed
,
Xenbase
Sabatini,
Analysis of calcium channels in single spines using optical fluctuation analysis.
2000,
Pubmed
Shelly,
Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation.
2010,
Pubmed
Shelly,
LKB1/STRAD promotes axon initiation during neuronal polarization.
2007,
Pubmed
Song,
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
1998,
Pubmed
,
Xenbase
Song,
A selective filter for cytoplasmic transport at the axon initial segment.
2009,
Pubmed
Stein,
RETRACTED: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.
2001,
Pubmed
,
Xenbase
Stornetta,
Ras and Rap signaling in synaptic plasticity and mental disorders.
2011,
Pubmed
Togashi,
Cyclic GMP-gated CNG channels function in Sema3A-induced growth cone repulsion.
2008,
Pubmed
,
Xenbase
Tran,
Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.
2009,
Pubmed
Uchida,
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.
2005,
Pubmed
Yi,
TGF-beta signaling specifies axons during brain development.
2010,
Pubmed
Yoshimura,
GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.
2005,
Pubmed
