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XB-ART-4390
Semin Cell Dev Biol August 1, 2003; 14 (4): 241-7.
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Kidney development conserved over species: essential roles of Sall1.

Nishinakamura R .


Abstract
The kidney develops in three stages: pronephros, mesonephros, and metanephros. Molecular mechanisms underlying these three steps are similar, and we can thus examine genetic cascades occurring during development. The induction system for pronephros in vitro has been established in Xenopus. Using this system, we isolated Sall1 that is essential for the initial step in metanephros formation. The potential mechanisms involved and future directions regarding kidney development are discussed.

PubMed ID: 14627123
Article link: Semin Cell Dev Biol


Species referenced: Xenopus
Genes referenced: sall1


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