Havens CG , Walter JC .

GM80676 NIGMS NIH HHS , R01 GM080676 NIGMS NIH HHS

Abbas, CRL4Cdt2: master coordinator of cell cycle progression and genome stability. 2011, Pubmed

Abbas, CRL4Cdt2: master coordinator of cell cycle progression and genome stability. 2011, Pubmed
Abbas, CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. 2010, Pubmed
Abbas, PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. 2008, Pubmed
Adimoolam, The p53-regulated cyclin-dependent kinase inhibitor, p21 (cip1, waf1, sdi1), is not required for global genomic and transcription-coupled nucleotide excision repair of UV-induced DNA photoproducts. 2001, Pubmed
Amador, APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. 2007, Pubmed
Angers, Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. 2006, Pubmed
Ardley, E3 ubiquitin ligases. 2005, Pubmed
Arias, Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. 2005, Pubmed , Xenbase
Arias, PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. 2006, Pubmed , Xenbase
Arias, Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. 2007, Pubmed
Asano, Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. 1996, Pubmed
Bates, Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression. 1998, Pubmed
Behrends, Constructing and decoding unconventional ubiquitin chains. 2011, Pubmed
Bendjennat, UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. 2003, Pubmed
Bornstein, Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. 2003, Pubmed
Braun, The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. 2011, Pubmed
Cayrol, p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. 1998, Pubmed
Cazzalini, p21CDKN1A does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent binding of DNA polymerase delta at the G1/S phase transition. 2003, Pubmed
Centore, CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. 2010, Pubmed , Xenbase
Chen, Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. 1995, Pubmed , Xenbase
Choe, The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. 2009, Pubmed
Chuang, The C-terminal domain of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1, is both necessary and sufficient for phosphorylation-independent proteolysis. 2005, Pubmed , Xenbase
Chuang, Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching. 2005, Pubmed , Xenbase
Cooper, The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo. 1999, Pubmed
Deshaies, RING domain E3 ubiquitin ligases. 2009, Pubmed
Deshaies, Control of cullin-ring ubiquitin ligase activity by nedd8. 2010, Pubmed
Dimova, The E2F transcriptional network: old acquaintances with new faces. 2005, Pubmed
Duda, Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. 2008, Pubmed
Fridman, Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair. 2010, Pubmed
Gao, Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. 2009, Pubmed
Guarino, Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation. 2011, Pubmed
Gulbis, Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. 1996, Pubmed
Hao, Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. 2007, Pubmed
Havens, Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. 2009, Pubmed , Xenbase
He, DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. 2006, Pubmed
Higa, Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. 2003, Pubmed
Higa, CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. 2006, Pubmed
Higa, Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy. 2007, Pubmed
Higa, L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. 2006, Pubmed
Hoege, RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. 2002, Pubmed
Hofmann, cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. 1994, Pubmed
Holmberg, Ddb1 controls genome stability and meiosis in fission yeast. 2005, Pubmed
Hon, Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. 2002, Pubmed
Hook, Mechanisms to control rereplication and implications for cancer. 2007, Pubmed
Houston, Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. 2008, Pubmed
Hu, WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. 2008, Pubmed
Hu, Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 2004, Pubmed
Hu, An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. 2006, Pubmed
Ishii, Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells. 2010, Pubmed
Ivan, HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. 2001, Pubmed
Jaakkola, Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. 2001, Pubmed
Jackson, CRL4s: the CUL4-RING E3 ubiquitin ligases. 2009, Pubmed
Jaspersen, Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. 1999, Pubmed
Jin, A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. 2006, Pubmed , Xenbase
Jin, Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. 2008, Pubmed , Xenbase
Jørgensen, SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. 2011, Pubmed
Kerns, Geminin prevents rereplication during xenopus development. 2007, Pubmed , Xenbase
Kim, The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA. 2010, Pubmed , Xenbase
Kim, The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. 2008, Pubmed
Kim, C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. 2007, Pubmed
Kim, Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans. 2008, Pubmed
Kim, The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. 2007, Pubmed
Komander, The emerging complexity of protein ubiquitination. 2009, Pubmed
Kondo, Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. 2004, Pubmed
Kraft, Mitotic regulation of the human anaphase-promoting complex by phosphorylation. 2003, Pubmed
Kramer, Mitotic regulation of the APC activator proteins CDC20 and CDH1. 2000, Pubmed , Xenbase
Lee, Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. 2010, Pubmed
Lee, Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation. 2007, Pubmed
Lee, Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. 2008, Pubmed
Li, AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. 2002, Pubmed
Li, The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. 2003, Pubmed
Li, Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. 2005, Pubmed , Xenbase
Lin, NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells. 2010, Pubmed
Liu, L2dtl is essential for cell survival and nuclear division in early mouse embryonic development. 2007, Pubmed
Liu, Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells. 2009, Pubmed
Liu, Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. 2005, Pubmed
Liu, Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms. 2003, Pubmed
Machida, Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation. 2005, Pubmed
Mailand, CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. 2005, Pubmed
McCall, Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. 2008, Pubmed
Medema, p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases. 1998, Pubmed
Michishita, Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis. 2011, Pubmed , Xenbase
Milhollen, Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover. 2011, Pubmed
Min, Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. 2002, Pubmed
Mizushima, Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase. 2007, Pubmed
Mockaitis, Auxin receptors and plant development: a new signaling paradigm. 2008, Pubmed
Moldovan, PCNA, the maestro of the replication fork. 2007, Pubmed
Moss, Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast. 2010, Pubmed
Nakanishi, The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition. 1995, Pubmed
Nestoras, Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms. 2010, Pubmed
Niculescu, Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. 1998, Pubmed
Nishitani, Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region. 2004, Pubmed
Nishitani, Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. 2006, Pubmed
Nishitani, CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. 2008, Pubmed
O'Connell, Ubiquitin proteasome system (UPS): what can chromatin do for you? 2007, Pubmed
Oda, Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. 2010, Pubmed
Perry, A SIM-ultaneous role for SUMO and ubiquitin. 2008, Pubmed
Pfleger, Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. 2001, Pubmed , Xenbase
Ralph, DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1. 2006, Pubmed
Raman, A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. 2011, Pubmed , Xenbase
Ravid, Diversity of degradation signals in the ubiquitin-proteasome system. 2008, Pubmed
Rice, Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. 2002, Pubmed
Rodrigo-Brenni, Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. 2010, Pubmed
Roukos, Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage. 2011, Pubmed
Saha, Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. 2011, Pubmed
Sansam, DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. 2006, Pubmed
Scott, Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. 2000, Pubmed
Scrima, Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. 2008, Pubmed
Senga, PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. 2006, Pubmed
Shibata, Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. 2011, Pubmed
Shibutani, Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. 2008, Pubmed
Soria, p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation. 2008, Pubmed
Soucy, An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. 2009, Pubmed
Stuart, Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells. 2009, Pubmed
Sugasawa, UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. 2005, Pubmed
Takeda, Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase. 2005, Pubmed
Tan, Hormone signaling through protein destruction: a lesson from plants. 2009, Pubmed
Tardat, The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. 2010, Pubmed
Teer, Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation. 2006, Pubmed
Terai, CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. 2010, Pubmed
Vaziri, A p53-dependent checkpoint pathway prevents rereplication. 2003, Pubmed
Waga, Dynamics of DNA binding of replication initiation proteins during de novo formation of pre-replicative complexes in Xenopus egg extracts. 2006, Pubmed , Xenbase
Wang, Tyrosine phosphorylation controls PCNA function through protein stability. 2006, Pubmed
Wang, Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection. 2005, Pubmed
Warbrick, A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. 1995, Pubmed
Wickliffe, The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. 2011, Pubmed
Wu, Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. 2010, Pubmed
Wu, A new regulator of the cell cycle: the PR-Set7 histone methyltransferase. 2011, Pubmed
Xu, DCAF26, an adaptor protein of Cul4-based E3, is essential for DNA methylation in Neurospora crassa. 2010, Pubmed
Ye, Building ubiquitin chains: E2 enzymes at work. 2009, Pubmed
Yen, Global protein stability profiling in mammalian cells. 2008, Pubmed
Yen, Identification of SCF ubiquitin ligase substrates by global protein stability profiling. 2008, Pubmed
Yin, SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail. 2008, Pubmed
Yoshida, E3 ubiquitin ligase that recognizes sugar chains. 2002, Pubmed
Yoshida, Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs. 2005, Pubmed , Xenbase
You, Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication. 2002, Pubmed , Xenbase
Yu, Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. 1998, Pubmed
Zachariae, Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. 1998, Pubmed
Zaidi, Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA. 2008, Pubmed
Zheng, Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. 2002, Pubmed
Zhong, CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. 2003, Pubmed