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Dev Cell January 17, 2012; 22 (1): 104-15.

A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration.

Weber GF , Bjerke MA , DeSimone DW .

Collective cell migration requires maintenance of adhesive contacts between adjacent cells, coordination of polarized cell protrusions, and generation of propulsive traction forces. We demonstrate that mechanical force applied locally to C-cadherins on single Xenopus mesendoderm cells is sufficient to induce polarized cell protrusion and persistent migration typical of individual cells within a collectively migrating tissue. Local tension on cadherin adhesions induces reorganization of the keratin intermediate filament network toward these stressed sites. Plakoglobin, a member of the catenin family, is localized to cadherin adhesions under tension and is required for both mechanoresponsive cell behavior and assembly of the keratin cytoskeleton at the rear of these cells. Local tugging forces on cadherins occur in vivo through interactions with neighboring cells, and these forces result in coordinate changes in cell protrusive behavior. Thus, cadherin-dependent force-inducible regulation of cell polarity in single mesendoderm cells represents an emergent property of the intact tissue.

PubMed ID: 22169071
PMC ID: PMC3264825
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cdh3 ckb ddx59 gap43 jup krt8.1
Morpholinos: jup MO1 krt8.1 MO1 krt8.1 MO2

Article Images: [+] show captions
References [+] :
ABERCROMBIE, Observations on the social behaviour of cells in tissue culture. I. Speed of movement of chick heart fibroblasts in relation to their mutual contacts. 1954, Pubmed