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Dev Dyn February 1, 2012; 241 (2): 403-14.
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Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis.

Hasebe T , Kajita M , Fu L , Shi YB , Ishizuya-Oka A .

BACKGROUND: During Xenopus laevis metamorphosis, Sonic hedgehog (Shh) is directly induced by thyroid hormone (TH) at the transcription level as one of the earliest events in intestinal remodeling. However, the regulation of other components of this signaling pathway remains to be analyzed. Here, we analyzed the spatiotemporal expression of Patched (Ptc)-1, Smoothened (Smo), Gli1, Gli2, and Gli3 during natural and TH-induced intestinal remodeling. RESULTS: We show that all of the genes examined are transiently up-regulated in the mesenchymal tissues during intestinal metamorphosis. CONCLUSIONS: Interestingly, in the presence of protein synthesis inhibitors, Gli2 but not the others was induced by TH, suggesting that Gli2 is a direct TH response gene, while the others are likely indirect ones. Furthermore, we demonstrate by the organ culture experiment that overexpression of Shh enhances the expression of Ptc-1, Smo, and Glis even in the absence of TH, indicating that Shh regulates its own pathway components during intestinal remodeling.

PubMed ID: 22190352
PMC ID: PMC3428560
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bmp4 gli1 gli2 gli3 myh3 pcna ptch1 shh smo

Article Images: [+] show captions
References [+] :
Agren, Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. 2004, Pubmed