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XB-ART-44724
Int J Dev Biol January 1, 2011; 55 (10-12): 923-31.

The RNA-binding protein Xp54nrb isolated from a Ca²+-dependent screen is expressed in neural structures during Xenopus laevis development.

Neant I , Deisig N , Scerbo P , Leclerc C , Moreau M .


Abstract
In amphibian embryos, calcium (Ca(2+)) signalling is a necessary and sufficient event to induce neural fate. Transient elevations of [Ca(2+)]i are recorded in neural tissue precursor cells in whole embryos during gastrulation. Using a subtractive cDNA library between control ectoderm (animal caps) and ectoderm induced toward a neural fate by Ca(2+) release, we have isolated several Ca(2+)-induced target genes. Among the isolated genes, Xp54nrb encodes a protein which exhibits the RRM domains characteristic of RNA binding proteins, and is implicated in pre-mRNA splicing steps. Here we show that the Xp54nrb transcripts are expressed throughout early developmental stages, specifically in the neural and sensorial territories and that Xp54nrb could be involved in anterior neural patterning.

PubMed ID: 22252489
Article link: Int J Dev Biol


Species referenced: Xenopus laevis
Genes referenced: ddx6 gal.2 nono pax3 pou3f4 rpe snai2 sox2 tbxt zic3
Morpholinos: nono MO1


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