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XB-ART-44775
Dev Cell 2012 Jan 17;221:3-4. doi: 10.1016/j.devcel.2011.12.018.
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Spurred by resistance: mechanosensation in collective migration.

Behrndt M , Heisenberg CP .


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How cells orchestrate their behavior during collective migration is a long-standing question. Using magnetic tweezers to apply mechanical stimuli to Xenopus mesendoderm cells, Weber et al. (2012) now reveal, in this issue of Developmental Cell, a cadherin-mediated mechanosensitive response that promotes cell polarization and movement persistence during the collective mesendoderm migration in gastrulation.

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Species referenced: Xenopus
Genes referenced: tbx2

References :
Weber, A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration. 2012, Pubmed, Xenbase