Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
2011 Nov 15;10846:E1184-91. doi: 10.1073/pnas.1114124108.
Show Gene links
Show Anatomy links
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli.
Cordero-Morales JF
,
Gracheva EO
,
Julius D
.
???displayArticle.abstract???
Transient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide array of physical and chemical stimuli, making them important components of sensory systems in both vertebrate and invertebrate organisms. Mammalian TRPA1 channels are activated by chemically reactive irritants, whereas snake and Drosophila TRPA1 orthologs are preferentially activated by heat. By comparing human and rattlesnake TRPA1 channels, we have identified two portable heat-sensitive modules within the ankyrin repeat-rich aminoterminal cytoplasmic domain of the snake ortholog. Chimeric channel studies further demonstrate that sensitivity to chemical stimuli and modulation by intracellular calcium also localize to the N-terminal ankyrin repeat-rich domain, identifying this region as an integrator of diverse physiological signals that regulate sensory neuron excitability. These findings provide a framework for understanding how restricted changes in TRPA1 sequence account for evolution of physiologically diverse channels, also identifying portable modules that specify thermosensitivity.
Bandell,
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.
2004, Pubmed
Bandell,
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.
2004,
Pubmed
Basbaum,
Cellular and molecular mechanisms of pain.
2009,
Pubmed
Bautista,
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
2006,
Pubmed
Bohlen,
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain.
2010,
Pubmed
,
Xenbase
Brauchi,
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels.
2006,
Pubmed
Caterina,
The vanilloid receptor: a molecular gateway to the pain pathway.
2001,
Pubmed
Caterina,
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
1997,
Pubmed
,
Xenbase
Chuang,
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel.
2004,
Pubmed
,
Xenbase
DeCoursey,
Temperature dependence of voltage-gated H+ currents in human neutrophils, rat alveolar epithelial cells, and mammalian phagocytes.
1998,
Pubmed
Doerner,
Transient receptor potential channel A1 is directly gated by calcium ions.
2007,
Pubmed
Gaudet,
A primer on ankyrin repeat function in TRP channels and beyond.
2008,
Pubmed
Gracheva,
Molecular basis of infrared detection by snakes.
2010,
Pubmed
Grandl,
Pore region of TRPV3 ion channel is specifically required for heat activation.
2008,
Pubmed
,
Xenbase
Grandl,
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.
2010,
Pubmed
Hamada,
An internal thermal sensor controlling temperature preference in Drosophila.
2008,
Pubmed
,
Xenbase
Hinman,
TRP channel activation by reversible covalent modification.
2006,
Pubmed
Jordt,
Acid potentiation of the capsaicin receptor determined by a key extracellular site.
2000,
Pubmed
Jordt,
Molecular basis for species-specific sensitivity to "hot" chili peppers.
2002,
Pubmed
Jordt,
Lessons from peppers and peppermint: the molecular logic of thermosensation.
2003,
Pubmed
Jordt,
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
2004,
Pubmed
Kang,
Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception.
2010,
Pubmed
Karashima,
TRPA1 acts as a cold sensor in vitro and in vivo.
2009,
Pubmed
Knowlton,
TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo.
2010,
Pubmed
Kohno,
Honey bee thermal/chemical sensor, AmHsTRPA, reveals neofunctionalization and loss of transient receptor potential channel genes.
2010,
Pubmed
Latorre,
ThermoTRP channels as modular proteins with allosteric gating.
2007,
Pubmed
Latorre,
Structure-functional intimacies of transient receptor potential channels.
2009,
Pubmed
Lishko,
The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity.
2007,
Pubmed
Macpherson,
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
2007,
Pubmed
McKemy,
Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
2002,
Pubmed
,
Xenbase
McNamara,
TRPA1 mediates formalin-induced pain.
2007,
Pubmed
Myers,
Evolution of thermal response properties in a cold-activated TRP channel.
2009,
Pubmed
Nilius,
Irritating channels: the case of TRPA1.
2011,
Pubmed
Peier,
A TRP channel that senses cold stimuli and menthol.
2002,
Pubmed
Phelps,
Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels.
2007,
Pubmed
Phelps,
Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.
2010,
Pubmed
Prescott,
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity.
2003,
Pubmed
,
Xenbase
Ramsey,
An introduction to TRP channels.
2006,
Pubmed
Rosenzweig,
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis.
2005,
Pubmed
Sotomayor,
In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats.
2005,
Pubmed
Story,
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
2003,
Pubmed
Tominaga,
The cloned capsaicin receptor integrates multiple pain-producing stimuli.
1998,
Pubmed
,
Xenbase
Trevisani,
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
2007,
Pubmed
Wang,
The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.
2008,
Pubmed
Werbeck,
Shifting transition states in the unfolding of a large ankyrin repeat protein.
2008,
Pubmed
Yang,
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
2010,
Pubmed
Yao,
Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels.
2011,
Pubmed
Zurborg,
Direct activation of the ion channel TRPA1 by Ca2+.
2007,
Pubmed
del Camino,
TRPA1 contributes to cold hypersensitivity.
2010,
Pubmed
