Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
The ability to form and maintain a functional system of contiguous hollow tubes is a critical feature of vascular endothelial cells (ECs). Lumen formation, or tubulogenesis, occurs in blood vessels during both vasculogenesis and angiogenesis in the embryo. Formation of vascular lumens takes place prior to the establishment of blood flow and to vascular remodeling which results in a characteristic hierarchical vessel organization. While epithelial lumen formation has received intense attention in past decades, more recent work has only just begun to elucidate the mechanisms controlling the initiation and morphogenesis of endothelial lumens. Studies using in vitro and in vivo models, including zebrafish and mammals, are beginning to paint an emerging picture of how blood vessels establish their characteristic morphology and become patent. In this article, we review and discuss the molecular and cellular mechanisms driving the formation of vascular tubes, primarily in vivo, and we compare and contrast proposed models for blood vessel lumen formation.
Aird,
Endothelial cell heterogeneity.
2003,
Pubmed
Andrew,
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.
2010,
Pubmed
Bayless,
The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices.
2002,
Pubmed
Bazzoni,
Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis.
2004,
Pubmed
Blum,
Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo.
2008,
Pubmed
Bryant,
A molecular network for de novo generation of the apical surface and lumen.
2010,
Pubmed
Carmeliet,
Mechanisms of angiogenesis and arteriogenesis.
2000,
Pubmed
Carmeliet,
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
1999,
Pubmed
Chappell,
Local guidance of emerging vessel sprouts requires soluble Flt-1.
2009,
Pubmed
Datta,
Molecular regulation of lumen morphogenesis.
2011,
Pubmed
Davis,
Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting.
2011,
Pubmed
Davis,
Mechanisms controlling human endothelial lumen formation and tube assembly in three-dimensional extracellular matrices.
2007,
Pubmed
Davis,
Capillary morphogenesis during human endothelial cell invasion of three-dimensional collagen matrices.
2000,
Pubmed
Dejana,
Endothelial cell-cell junctions: happy together.
2004,
Pubmed
Dekan,
Binding of monoclonal antibodies to glomerular endothelium, slit membranes, and epithelium after in vivo injection. Localization of antigens and bound IgGs by immunoelectron microscopy.
1990,
Pubmed
Drake,
Avian vasculogenesis and the distribution of collagens I, IV, laminin, and fibronectin in the heart primordia.
1990,
Pubmed
Drake,
Vasculogenesis in the day 6.5 to 9.5 mouse embryo.
2000,
Pubmed
Drake,
Perturbation of beta 1 integrin-mediated adhesions results in altered somite cell shape and behavior.
1992,
Pubmed
Drake,
An antagonist of integrin alpha v beta 3 prevents maturation of blood vessels during embryonic neovascularization.
1995,
Pubmed
Ferrari,
ROCK-mediated contractility, tight junctions and channels contribute to the conversion of a preapical patch into apical surface during isochoric lumen initiation.
2008,
Pubmed
Furness,
Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis.
2006,
Pubmed
George,
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin.
1993,
Pubmed
George,
Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells.
1997,
Pubmed
Gerhardt,
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
2003,
Pubmed
Gory-Fauré,
Role of vascular endothelial-cadherin in vascular morphogenesis.
1999,
Pubmed
Greiner,
Rac1 regulates pancreatic islet morphogenesis.
2009,
Pubmed
Guillemin,
The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system.
1996,
Pubmed
Herbert,
Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation.
2009,
Pubmed
Hogan,
Organogenesis: molecular mechanisms of tubulogenesis.
2002,
Pubmed
Holderfield,
Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis.
2008,
Pubmed
Horne-Badovinac,
Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis.
2001,
Pubmed
Hynes,
Integrins: bidirectional, allosteric signaling machines.
2002,
Pubmed
Hynes,
Cell-matrix adhesion in vascular development.
2007,
Pubmed
Iruela-Arispe,
Cellular and molecular mechanisms of vascular lumen formation.
2009,
Pubmed
Isogai,
Angiogenic network formation in the developing vertebrate trunk.
2003,
Pubmed
Jakobsson,
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow.
2008,
Pubmed
Jin,
Cellular and molecular analyses of vascular tube and lumen formation in zebrafish.
2005,
Pubmed
,
Xenbase
Kamei,
Endothelial tubes assemble from intracellular vacuoles in vivo.
2006,
Pubmed
Kesavan,
Cdc42-mediated tubulogenesis controls cell specification.
2009,
Pubmed
Koh,
Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.
2008,
Pubmed
Lei,
Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling.
2008,
Pubmed
Levi,
Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization.
2006,
Pubmed
Lipschutz,
Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins.
2000,
Pubmed
Liu,
Ccm1 regulates microvascular morphogenesis during angiogenesis.
2011,
Pubmed
Lubarsky,
Tube morphogenesis: making and shaping biological tubes.
2003,
Pubmed
Luo,
N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis.
2005,
Pubmed
Macara,
Par proteins: partners in polarization.
2004,
Pubmed
Meder,
Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.
2005,
Pubmed
Medioni,
Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation.
2008,
Pubmed
Mitin,
Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.
2004,
Pubmed
Navarro,
Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization.
1998,
Pubmed
Nielsen,
CD34 is a key regulator of hematopoietic stem cell trafficking to bone marrow and mast cell progenitor trafficking in the periphery.
2009,
Pubmed
O'Brien,
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly.
2001,
Pubmed
Pirraglia,
Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape.
2010,
Pubmed
Risau,
Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis.
1988,
Pubmed
Risau,
Vasculogenesis.
1995,
Pubmed
Sacharidou,
Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events.
2010,
Pubmed
Santiago-Martínez,
Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation.
2008,
Pubmed
Saunders,
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.
2006,
Pubmed
Streuli,
Integrins and cell-fate determination.
2009,
Pubmed
Strilić,
The molecular basis of vascular lumen formation in the developing mouse aorta.
2009,
Pubmed
Strilić,
Electrostatic cell-surface repulsion initiates lumen formation in developing blood vessels.
2010,
Pubmed
Stuart,
Epithelial tubulogenesis through branching morphogenesis: relevance to collecting system development.
1995,
Pubmed
Tanjore,
Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis.
2008,
Pubmed
Vega-Salas,
Exocytosis of vacuolar apical compartment (VAC): a cell-cell contact controlled mechanism for the establishment of the apical plasma membrane domain in epithelial cells.
1988,
Pubmed
Wang,
Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis.
2010,
Pubmed
Xu,
Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.
2011,
Pubmed
,
Xenbase
Xu,
Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation.
2009,
Pubmed
,
Xenbase
Yang,
Embryonic mesodermal defects in alpha 5 integrin-deficient mice.
1993,
Pubmed
Yeaman,
New perspectives on mechanisms involved in generating epithelial cell polarity.
1999,
Pubmed
Zeeb,
Resolving cell-cell junctions: lumen formation in blood vessels.
2010,
Pubmed
Zovein,
Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.
2010,
Pubmed
