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XB-ART-45191
Phys Rev Lett 2012 Feb 03;1085:058101. doi: 10.1103/PhysRevLett.108.058101.
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Optimal placement of origins for DNA replication.

Karschau J , Blow JJ , de Moura AP .


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DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.

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Species referenced: Xenopus laevis

References [+] :
Blow, Replication origins in Xenopus egg extract Are 5-15 kilobases apart and are activated in clusters that fire at different times. 2001, Pubmed, Xenbase