Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-45352
Development July 1, 2012; 139 (14): 2557-65.
Show Gene links Show Anatomy links

Transient downregulation of Bmp signalling induces extra limbs in vertebrates.

Christen B , Rodrigues AM , Monasterio MB , Roig CF , Izpisua Belmonte JC .


Abstract
Bone morphogenetic protein (Bmp) signalling has been implicated in setting up dorsoventral patterning of the vertebrate limb and in its outgrowth. Here, we present evidence that Bmp signalling or, more precisely, its inhibition also plays a role in limb and fin bud initiation. Temporary inhibition of Bmp signalling either by overexpression of noggin or using a synthetic Bmp inhibitor is sufficient to induce extra limbs in the Xenopus tadpole or exogenous fins in the Danio rerio embryo, respectively. We further show that Bmp signalling acts in parallel with retinoic acid signalling, possibly by inhibiting the known limb-inducing gene wnt2ba.

PubMed ID: 22675213
Article link: Development


Species referenced: Xenopus laevis
Genes referenced: alk bmp2 bmp4 bmp7.1 en1 fgf10 fgf8 galk1 galk2 lmx1a lmx1b.1 nog smad1 smad3 sp8 wnt2b wnt3a wnt7a
Antibodies: Smad1 Ab7 Smad2 Ab4 Tuba4b Ab8

Phenotypes: Xla.Tg(hsp70:nog,cryga:GFP) + HS (A) [+]

Article Images: [+] show captions