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Int J Dev Biol January 1, 2012; 56 (5): 333-9.

Identification and characterization of ADAM41, a novel ADAM metalloproteinase in Xenopus.

Xu G , Wei S , White JM , DeSimone DW .

The ADAM family of transmembrane metalloproteinases has important functions in fertilization, development and disease, and is widely distributed throughout the Metazoa. In this study, we identified a novel ADAM protein in Xenopus tropicalis (X. tropicalis) with closest overall sequence similarity to the Xenopus ADAM10 protein. Based on comparisons of available sequence information, putative orthologs of this ADAM (which we designate ADAM41) are identified in several other vertebrate species including non-placental mammals, but absent from placental mammals and aves. ADAM41 mRNA is maternally deposited in X. tropicalis with subsequent zygotic expression detected in the neural plate at neurula stages. Antisense morpholino knockdown of ADAM41 results in a delay in early neuronal marker expression, which can be rescued by a non-targeted ADAM41 transcript. Thus, ADAM41 is likely required for maintaining proper timing of neurogenesis in X. tropicalis.

PubMed ID: 22811267
PMC ID: PMC3695402
Article link: Int J Dev Biol
Grant support: [+]

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: adam10 myc neurog2 notch1 tubb2b

Article Images: [+] show captions
References [+] :
Blobel, ADAMs: key components in EGFR signalling and development. 2005, Pubmed