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Opt Lett July 15, 2012; 37 (14): 2979-81.
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Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography.

Deniz E , Jonas S , Khokha M , Choma MA .

The genetic basis of congenital heart disease is yet to be defined, and the interactions between the malformed heart and biomechanical cardiac performance remain poorly understood. Functional optical imaging enables detailed biomechanical phenotyping of cardiac dysfunction in small animal models, which in turn enables specific gene-phenotype relationship. We have developed a new microangiography technique based on flow imaging using endogenous hemoglobin contrast enabling in vivo assessment and biomechanical phenotyping of Xenopus tropicalis embryonic heart. We demonstrated that hemoglobin contrast angiography can be used to quantify physiological response to treatment with well-established cardioactive drugs.

PubMed ID: 22825198
PMC ID: PMC3881542
Article link: Opt Lett
Grant support: [+]

References [+] :
Gono, Appearance of enhanced tissue features in narrow-band endoscopic imaging. 2004, Pubmed