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Development December 1, 2003; 130 (23): 5649-61.
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The RNA-binding protein Vg1 RBP is required for cell migration during early neural development.

Yaniv K , Fainsod A , Kalcheim C , Yisraeli JK .

After mid-blastula transition, populations of cells within the Xenopus embryo become motile. Using antisense morpholino oligonucleotides, we find that Vg1 RBP, an RNA-binding protein implicated in RNA localization in oocytes, is required for the migration of cells forming the roof plate of the neural tube and, subsequently, for neural crest migration. These cells are properly determined but remain at their site of origin. Consistent with a possible role in cell movement, Vg1 RBP asymmetrically localizes to extended processes in migrating neural crest cells. Given that Vg1 RBP is a member of the conserved VICKZ family of proteins, expressed in embryonic and neoplastic cells, these data shed light on the likely role of these RNA-binding proteins in regulating cell movements during both development and metastasis.

PubMed ID: 14522877
Article link: Development

Species referenced: Xenopus laevis
Genes referenced: b3gat1l fn1 gdf1 igf2bp3 mapk1 pax3 snai1 twist1
Morpholinos: igf2bp3 MO1

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