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XB-ART-46214
Methods Mol Biol January 1, 2013; 935 113-25.
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Generation of transgenic X. laevis models of retinal degeneration.

Tam BM , Lai CC , Zong Z , Moritz OL .


Abstract
Transgenic models are invaluable tools for researching retinal degenerative disease mechanisms. However, they are time-consuming and expensive to generate and maintain. We have developed an alternative to transgenic rodent models of retinal degeneration using transgenic Xenopus laevis. We have optimized this system to allow rapid analysis of transgene effects in primary transgenic animals, thereby providing an alternative to establishing transgenic lines, and simultaneously allowing rigorous comparisons between the effects of different transgenes.

PubMed ID: 23150364
Article link: Methods Mol Biol
Grant support: [+]