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XB-ART-46253
Differentiation September 1, 2004; 72 (7): 307-18.
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Cross-regulation of Wnt signaling and cell adhesion.

Schambony A , Kunz M , Gradl D .


Abstract
The complex cross-regulation between Wnt signaling, cell-cell adhesion, and cell-matrix adhesion has revealed a number of regulatory components important in development and cancer progression. In the following, we would like to highlight and summarize some of the steps where pathways converge or diverge in regulating Wnt activity, matrix-induced pathways, and cell adhesion. We would like to focus on the involvement of heparan sulfate proteoglycan-rich proteins (HSPGs), integrin-mediated outside-in signaling, and cadherin-mediated cell-cell adhesion on Wnt pathways and the transcriptional regulation of extracellular matrix components and cell adhesion molecules by Wnt signaling.

PubMed ID: 15554942
Article link: Differentiation


Species referenced: Xenopus
Genes referenced: ccn1 ccn4 cdh1 cdh2 celsr1 celsr2 celsr3 cnn1 col2a1 ctnnb1 fn1 gpc3 gpc4 gsk3b itga3 itgb1 jun lef1 mapk8 mmp21 pcdh8 szl tcf7 tcf7l1 wnt1 wnt5a wnt7a wnt8a