Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
PLoS One January 1, 2012; 7 (6): e39572.

The biochemical anatomy of cortical inhibitory synapses.

Heller EA , Zhang W , Selimi F , Earnheart JC , Ślimak MA , Santos-Torres J , Ibañez-Tallon I , Aoki C , Chait BT , Heintz N .

Classical electron microscopic studies of the mammalian brain revealed two major classes of synapses, distinguished by the presence of a large postsynaptic density (PSD) exclusively at type 1, excitatory synapses. Biochemical studies of the PSD have established the paradigm of the synapse as a complex signal-processing machine that controls synaptic plasticity. We report here the results of a proteomic analysis of type 2, inhibitory synaptic complexes isolated by affinity purification from the cerebral cortex. We show that these synaptic complexes contain a variety of neurotransmitter receptors, neural cell-scaffolding and adhesion molecules, but that they are entirely lacking in cell signaling proteins. This fundamental distinction between the functions of type 1 and type 2 synapses in the nervous system has far reaching implications for models of synaptic plasticity, rapid adaptations in neural circuits, and homeostatic mechanisms controlling the balance of excitation and inhibition in the mature brain.

PubMed ID: 22768092
PMC ID: PMC3387162
Article link: PLoS One
Grant support: [+]

Species referenced: Xenopus
Genes referenced: camk2g dlg4 gabarap gabra1 gad1.2 gria2 homer1 hspa5 lhfpl3 lhfpl4 nbea nlgn2 nlgn3 osbpl8 otx1 psd rbfox3

Article Images: [+] show captions
References [+] :
Aoki, Use of electron microscopy in the detection of adrenergic receptors. 2000, Pubmed