XB-ART-46504
Genome Biol
2012 Oct 22;1310:251. doi: 10.1186/gb-2012-13-10-251.
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The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.
Schmidt R
,
Plath K
.
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ABSTRACT: Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.
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T32 GM008042 NIGMS NIH HHS
Species referenced: Xenopus
Genes referenced: dpy30 isyna1 klf4 pou5f3 smarcc1 smarcc2 sox2 taf5 taf6 taf7 tbp tbx2 wdr5
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