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Development
2013 May 01;1409:1970-80. doi: 10.1242/dev.088104.
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Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock.
Hashiguchi M
,
Mullins MC
.
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Establishment of the body plan in vertebrates depends on the temporally coordinated patterning of tissues along the body axes. We have previously shown that dorsoventral (DV) tissues are temporally patterned progressively from anterior to posterior by a BMP signaling pathway. Here we report that DV patterning along the zebrafish anteroposterior (AP) axis is temporally coordinated with AP patterning by an identical patterning clock. We altered AP patterning by inhibiting or activating FGF, Wnt or retinoic acid signaling combined with inhibition of BMP signaling at a series of developmental time points, which revealed that the temporal progression of DV patterning is directly coordinated with AP patterning. We investigated how these signaling pathways are integrated and suggest a model for how DV and AP patterning are temporally coordinated. It has been shown that in Xenopus dorsal tissues FGF and Wnt signaling quell BMP signaling by degrading phosphorylated (P) Smad1/5, the BMP pathway signal transducer, via phosphorylation of the Smad1/5 linker region. We show that in zebrafish FGF/MAPK, but not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes to a ventral vegetal gastrula region that could coordinate DV patterning with AP patterning ventrally without degrading P-Smad1/5. Furthermore, we demonstrate that alteration of the MAPK phosphorylation sites in the Smad5 linker causes precocious patterning of DV tissues along the AP axis during gastrulation. Thus, DV and AP patterning are intimately coordinated to allow cells to acquire both positional and temporal information simultaneously.
Alexandre,
Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype.
1996, Pubmed
Alexandre,
Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype.
1996,
Pubmed
Dick,
Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo.
1999,
Pubmed
Erter,
Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer.
1998,
Pubmed
Erter,
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.
2001,
Pubmed
,
Xenbase
Fuentealba,
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.
2007,
Pubmed
,
Xenbase
Fürthauer,
Fgf signalling controls the dorsoventral patterning of the zebrafish embryo.
2004,
Pubmed
Gamse,
Vertebrate anteroposterior patterning: the Xenopus neurectoderm as a paradigm.
2000,
Pubmed
,
Xenbase
Gamse,
Early anteroposterior division of the presumptive neurectoderm in Xenopus.
2001,
Pubmed
,
Xenbase
Grinblat,
Determination of the zebrafish forebrain: induction and patterning.
1998,
Pubmed
,
Xenbase
Hans,
Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b.
2007,
Pubmed
Hans,
Changes in retinoic acid signaling alter otic patterning.
2007,
Pubmed
Hao,
In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.
2010,
Pubmed
Hild,
The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo.
1999,
Pubmed
Houart,
Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling.
2002,
Pubmed
Kim,
Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish.
2002,
Pubmed
,
Xenbase
Klein,
A molecular mechanism for the effect of lithium on development.
1996,
Pubmed
,
Xenbase
Kobayashi,
Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish.
1998,
Pubmed
Kramer,
Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling.
2002,
Pubmed
Krauss,
Zebrafish pax[b] is involved in the formation of the midbrain-hindbrain boundary.
1992,
Pubmed
Kudoh,
Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm.
2002,
Pubmed
Kudoh,
Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains.
2004,
Pubmed
Langdon,
Maternal and zygotic control of zebrafish dorsoventral axial patterning.
2011,
Pubmed
Leptin,
Gastrulation movements: the logic and the nuts and bolts.
2005,
Pubmed
Li,
Expression of two zebrafish orthodenticle-related genes in the embryonic brain.
1994,
Pubmed
Little,
Extracellular modulation of BMP activity in patterning the dorsoventral axis.
2006,
Pubmed
,
Xenbase
Maden,
Retinoid signalling in the development of the central nervous system.
2002,
Pubmed
Maegawa,
FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer.
2006,
Pubmed
Maves,
Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid.
2005,
Pubmed
Mohammadi,
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
1997,
Pubmed
Montero,
Gastrulation dynamics: cells move into focus.
2004,
Pubmed
Mori,
Different spatio-temporal expressions of three otx homeoprotein transcripts during zebrafish embryogenesis.
1994,
Pubmed
Mullins,
Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes.
1996,
Pubmed
Nguyen,
Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway.
2000,
Pubmed
Oxtoby,
Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development.
1993,
Pubmed
Prince,
Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino.
1998,
Pubmed
Ramel,
WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation.
2005,
Pubmed
Rebagliati,
Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry.
1998,
Pubmed
,
Xenbase
Rebagliati,
cyclops encodes a nodal-related factor involved in midline signaling.
1998,
Pubmed
Rhinn,
Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling.
2003,
Pubmed
Rhinn,
Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling.
2005,
Pubmed
Russo,
Inhibition of mouse cytosolic aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde.
1988,
Pubmed
Sampath,
Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.
1998,
Pubmed
,
Xenbase
Schier,
Molecular genetics of axis formation in zebrafish.
2005,
Pubmed
Schulte-Merker,
The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo.
1992,
Pubmed
Schumacher,
An intermediate level of BMP signaling directly specifies cranial neural crest progenitor cells in zebrafish.
2011,
Pubmed
Sheng,
Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1.
2010,
Pubmed
Shimizu,
Interaction of Wnt and caudal-related genes in zebrafish posterior body formation.
2005,
Pubmed
Shimono,
Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.
2011,
Pubmed
Solnica-Krezel,
Conserved patterns of cell movements during vertebrate gastrulation.
2005,
Pubmed
Stern,
Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?
2006,
Pubmed
Stoick-Cooper,
Distinct Wnt signaling pathways have opposing roles in appendage regeneration.
2007,
Pubmed
Takebayashi-Suzuki,
The forkhead transcription factor FoxB1 regulates the dorsal-ventral and anterior-posterior patterning of the ectoderm during early Xenopus embryogenesis.
2011,
Pubmed
,
Xenbase
Thisse,
Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo.
2000,
Pubmed
Tucker,
The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis.
2008,
Pubmed
Wilson,
Early steps in the development of the forebrain.
2004,
Pubmed
Woo,
Specification of the hindbrain fate in the zebrafish.
1998,
Pubmed
Yin,
Convergence and extension movements during vertebrate gastrulation.
2009,
Pubmed
van de Water,
Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant.
2001,
Pubmed
von der Hardt,
The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion.
2007,
Pubmed
