Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Sci Rep January 1, 2011; 1 68.
Show Gene links Show Anatomy links

β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion.

Takezawa Y , Yoshida K , Miyado K , Sato M , Nakamura A , Kawano N , Sakakibara K , Kondo T , Harada Y , Ohnami N , Kanai S , Miyado M , Saito H , Takahashi Y , Akutsu H , Umezawa A .

When a sperm and an oocyte unite upon fertilization, their cell membranes adhere and fuse, but little is known about the factors regulating sperm-oocyte adhesion. Here we explored the role of β-catenin in sperm-oocyte adhesion. Biochemical analysis revealed that E-cadherin and β-catenin formed a complex in oocytes and also in sperm. Sperm-oocyte adhesion was impaired when β-catenin-deficient oocytes were inseminated with sperm. Furthermore, expression of β-catenin decreased from the sperm head and the site of an oocyte to which a sperm adheres after completion of sperm-oocyte adhesion. UBE1-41, an inhibitor of ubiquitin-activating enzyme 1, inhibited the degradation of β-catenin, and reduced the fusing ability of wild-type (but not β-catenin-deficient) oocytes. These results indicate that β-catenin is not only involved in membrane adhesion, but also in the transition to membrane fusion upon fertilization.

PubMed ID: 22355587
PMC ID: PMC3216555
Article link: Sci Rep

Species referenced: Xenopus
Genes referenced: actl6a cd9 cdh1 cdh2 ctnnb1 fubp1 gnl3 uba1

Article Images: [+] show captions
References [+] :
Aberle, beta-catenin is a target for the ubiquitin-proteasome pathway. 1997, Pubmed