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Bioessays January 1, 2014; 36 (1): 27-33.

Carbohydrate metabolism during vertebrate appendage regeneration: what is its role? How is it regulated?: A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis.

Love NR , Ziegler M , Chen Y , Amaya E .

We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate that these changes in gene expression play an essential role during regeneration by stimulating the anabolic pathways required for the reconstruction of a new appendage. We hypothesize that during regeneration, cells use leptin, slc2a3, proinsulin, g6pd, hif1α expression, receptor tyrosine kinase (RTK) signaling, and the production of reactive oxygen species (ROS) to promote glucose entry into glycolysis and the pentose phosphate pathway (PPP), thus stimulating macromolecular biosynthesis. We suggest that this metabolic shift is integral to the appendage regeneration program and that the Xenopus model is a powerful experimental system to further explore this phenomenon. Also watch the Video Abstract.

PubMed ID: 24264888
PMC ID: PMC3992846
Article link: Bioessays
Grant support: [+]

Species referenced: Xenopus
Genes referenced: akt1 bgn g6pd hpse kdr lep pfkm prkg1 slc2a3 tkt tpi1 ubl4a

Article Images: [+] show captions
References [+] :
Agathocleous, Metabolism in physiological cell proliferation and differentiation. 2013, Pubmed