XB-ART-48201
Cold Spring Harb Perspect Biol
2013 Feb 01;52:. doi: 10.1101/cshperspect.a008011.
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Wnt signaling in normal and malignant hematopoiesis.
Lento W
,
Congdon K
,
Voermans C
,
Kritzik M
,
Reya T
.
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One of the most remarkable characteristics of stem cells is their ability to perpetuate themselves through self-renewal while concomitantly generating differentiated cells. In the hematopoietic system, stem cells balance these mechanisms to maintain steady-state hematopoiesis for the lifetime of the organism, and to effectively regenerate the system following injury. Defects in the proper control of self-renewal and differentiation can be potentially devastating and contribute to the development of malignancies. In this review, we trace the emerging role of Wnt signaling as a critical regulator of distinct aspects of self-renewal and differentiation, its contribution to the maintenance of homeostasis and regeneration, and how the pathway can be hijacked to promote leukemia development. A better understanding of these processes could pave the way to enhancing recovery after injury and to developing better therapeutic approaches for hematologic malignancies.
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T32 HD040372 NICHD NIH HHS
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