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Nat Rev Mol Cell Biol May 1, 2009; 10 (5): 332-43.
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The trip of the tip: understanding the growth cone machinery.

Lowery LA , Van Vactor D .

The central component in the road trip of axon guidance is the growth cone, a dynamic structure that is located at the tip of the growing axon. During its journey, the growth cone comprises both ''vehicle'' and ''navigator''. Whereas the ''vehicle'' maintains growth cone movement and contains the cytoskeletal structural elements of its framework, a motor to move forward and a mechanism to provide traction on the ''road'', the ''navigator'' aspect guides this system with spatial bias to translate environmental signals into directional movement. The understanding of the functions and regulation of the vehicle and navigator provides new insights into the cell biology of growth cone guidance.

PubMed ID: 19373241
PMC ID: PMC2714171
Article link: Nat Rev Mol Cell Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: lrrfip1

References [+] :
Ahuja, Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 2007, Pubmed