Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-49891
Dev Biol December 1, 2013; 384 (1): 26-40.
Show Gene links Show Anatomy links

Maturin is a novel protein required for differentiation during primary neurogenesis.

Martinez-De Luna RI , Ku RY , Lyou Y , Zuber ME .


Abstract
Proliferation and differentiation are tightly controlled during neural development. In the embryonic neural plate, primary neurogenesis is driven by the proneural pathway. Here we report the characterization of Maturin, a novel, evolutionarily conserved protein that is required for normal primary neurogenesis. Maturin is detected throughout the early nervous system, yet it is most strongly expressed in differentiating neurons of the embryonic fish, frog and mouse nervous systems. Maturin expression can be induced by the proneural transcription factors Neurog2, Neurod1, and Ebf3. Maturin overexpression promotes neurogenesis, while loss-of-function inhibits the differentiation of neuronal progenitors, resulting in neural plate expansion. Maturin knockdown blocks the ability of Neurog2, Neurod1, and Ebf3 to drive ectopic neurogenesis. Maturin and Pak3, are both required for, and can synergize to promote differentiation of the primary neurons in vivo. Together, our results suggest that Maturin functions during primary neurogenesis and is required for the proneural pathway to regulate neural differentiation.

PubMed ID: 24095902
PMC ID: PMC3843043
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: actc1 actl6a ebf3 gnl3 h4c4 mturn ncam1 neurod1 neurog2 nog numbl pak3 pcna pnma2 rax sox2 tbx2 tubb2b
Morpholinos: mturn MO1 mturn MO2 pak3 MO1


Article Images: [+] show captions
References [+] :
Agathocleous, From progenitors to differentiated cells in the vertebrate retina. 2009, Pubmed