XB-ART-50382Cytotechnology August 1, 2015; 67 (4): 711-9.
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Spatiotemporal expression of Prdm genes during Xenopus development.
Epigenetic regulation is known to be important in embryonic development, cell differentiation and regulation of cancer cells. Molecular mechanisms of epigenetic modification have DNA methylation and histone tail modification such as acetylation, phosphorylation and ubiquitination. Until now, many kinds of enzymes that modify histone tail with various functional groups have been reported and regulate the epigenetic state of genes. Among them, Prdm genes were identified as histone methyltransferase. Prdm genes are characterized by an N-terminal PR/SET domain and C-terminal some zinc finger domains and therefore they are considered to have both DNA-binding ability and methylation activity. Among vertebrate, fifteen members are estimated to belong to Prdm genes family. Even though Prdm genes are thought to play important roles for cell fate determination and cell differentiation, there is an incomplete understanding of their expression and functions in early development. Here, we report that Prdm genes exhibit dynamic expression pattern in Xenopus embryogenesis. By whole mount in situ hybridization analysis, we show that Prdm genes are expressed in spatially localized manners in embryo and all of Prdm genes are expressed in neural cells in developing central nervous systems. Our study suggests that Prdm genes may be new candidates to function in neural cell differentiation.
PubMed ID: 25690332
PMC ID: PMC4474993
Article link: Cytotechnology
Species referenced: Xenopus
Genes referenced: prdm1 prdm10 prdm11 prdm12 prdm13 prdm14 prdm15 prdm16 prdm2 prdm4 prdm5 prdm6 prdm8 XB5904899 [provisional]
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References [+] :
Aagaard, Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. 1999, Pubmed