Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Physiol
2014 Jun 15;59212:2563-74. doi: 10.1113/jphysiol.2014.272880.
Show Gene links
Show Anatomy links
Smooth muscle BK channel activity influences blood pressure independent of vascular tone in mice.
Sachse G
,
Faulhaber J
,
Seniuk A
,
Ehmke H
,
Pongs O
.
???displayArticle.abstract???
The large conductance voltage- and Ca(2+)-activated K(+) (BK) channel is an important determinant of vascular tone and contributes to blood pressure regulation. Both activities depend on the ancillary BKβ1 subunit. To determine the significance of smooth muscle BK channel activity for blood pressure regulation, we investigated the potential link between changes in arterial tone and altered blood pressure in BKβ1 knockout (BKβ1(-/-)) mice from three different genetically defined strains. While vascular tone was consistently increased in all BKβ1(-/-) mice independent of genetic background, BKβ1(-/-) strains exhibited increased (strain A), unaltered (strain B) or decreased (strain C) mean arterial blood pressures compared to their corresponding BKβ1(+/+) controls. In agreement with previous data on aldosterone regulation by renal/adrenal BK channel function, BKβ1(-/-) strain A mice have increased plasma aldosterone and increased blood pressure. Consistently, blockade of mineralocorticoid receptors by spironolactone treatment reversibly restored the elevated blood pressure to the BKβ1(+/+) strain A level. In contrast, loss of BKβ1 did not affect plasma aldosterone in strain C mice. Smooth muscle-restricted restoration of BKβ1 expression increased blood pressure in BKβ1(-/-) strain C mice, implying that impaired smooth muscle BK channel activity lowers blood pressure in these animals. We conclude that BK channel activity directly affects vascular tone but influences blood pressure independent of this effect via different pathways.
Amberg,
Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension.
2003, Pubmed
Amberg,
Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension.
2003,
Pubmed
Amberg,
Downregulation of the BK channel beta1 subunit in genetic hypertension.
2003,
Pubmed
Behrens,
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.
2000,
Pubmed
Brenner,
Vasoregulation by the beta1 subunit of the calcium-activated potassium channel.
2000,
Pubmed
Briet,
Aldosterone: effects on the kidney and cardiovascular system.
2010,
Pubmed
Butz,
Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool.
2001,
Pubmed
Campen,
Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice.
2002,
Pubmed
Chau,
Essential hypertension: an approach to clinical data by the use of models.
1979,
Pubmed
Chen,
Renal failure in mice with Gsalpha deletion in juxtaglomerular cells.
2010,
Pubmed
Coffman,
Kidney in hypertension: guyton redux.
2008,
Pubmed
Cox,
Role of the beta1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivity.
2000,
Pubmed
,
Xenbase
Faraci,
Role of potassium channels in regulation of cerebral vascular tone.
1998,
Pubmed
Fernández-Fernández,
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.
2004,
Pubmed
Gerthoffer,
Secretory functions of smooth muscle: cytokines and growth factors.
2002,
Pubmed
Golde,
A rapid, simple, and humane method for submandibular bleeding of mice using a lancet.
2005,
Pubmed
Gollasch,
K+ currents in human coronary artery vascular smooth muscle cells.
1996,
Pubmed
Grimm,
Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism.
2009,
Pubmed
Grimm,
BK channels and a new form of hypertension.
2010,
Pubmed
Gödecke,
Coronary hemodynamics in endothelial NO synthase knockout mice.
1998,
Pubmed
Harrap,
Where are all the blood-pressure genes?
2003,
Pubmed
Howitt,
Differential effects of diet-induced obesity on BKCa {beta}1-subunit expression and function in rat skeletal muscle arterioles and small cerebral arteries.
2011,
Pubmed
Jackson,
Potassium channels in the peripheral microcirculation.
2005,
Pubmed
Johnson,
The activated mesangial cell: a glomerular "myofibroblast"?
1992,
Pubmed
Just,
Autonomic cardiovascular control in conscious mice.
2000,
Pubmed
Kelley-Hedgepeth,
The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade.
2008,
Pubmed
Kokubo,
Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study.
2005,
Pubmed
Ledoux,
Calcium-activated potassium channels and the regulation of vascular tone.
2006,
Pubmed
Li,
Reduction of large-conductance Ca²(+) -activated K(+) channel with compensatory increase of nitric oxide in insulin resistant rats.
2011,
Pubmed
Lifton,
Molecular mechanisms of human hypertension.
2001,
Pubmed
Lum,
Cardiovascular and renal phenotype in mice with one or two renin genes.
2004,
Pubmed
Löhn,
beta(1)-Subunit of BK channels regulates arterial wall[Ca(2+)] and diameter in mouse cerebral arteries.
2001,
Pubmed
Mack,
Regulation of smooth muscle alpha-actin expression in vivo is dependent on CArG elements within the 5' and first intron promoter regions.
1999,
Pubmed
Magnusson,
Renovascular BK(Ca) channels are not activated in vivo under resting conditions and during agonist stimulation.
2007,
Pubmed
Mattson,
Long-term measurement of arterial blood pressure in conscious mice.
1998,
Pubmed
Mérillat,
Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g.
2009,
Pubmed
Nelson,
Physiological roles and properties of potassium channels in arterial smooth muscle.
1995,
Pubmed
Pluznick,
Renal fluid and electrolyte handling in BKCa-beta1-/- mice.
2003,
Pubmed
Pluznick,
BK-{beta}1 subunit: immunolocalization in the mammalian connecting tubule and its role in the kaliuretic response to volume expansion.
2005,
Pubmed
Plüger,
Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure.
2000,
Pubmed
Pérez,
Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries.
1999,
Pubmed
Rubanyi,
Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption.
1997,
Pubmed
Schlager,
Selection for blood pressure levels in mice.
1974,
Pubmed
Sorensen,
Closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats.
2011,
Pubmed
Sprossmann,
Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder.
2009,
Pubmed
Wu,
The BK potassium channel in the vascular smooth muscle and kidney: α- and β-subunits.
2010,
Pubmed
Xu,
Large-conductance Ca2+-activated K+ channel beta1-subunit knockout mice are not hypertensive.
2011,
Pubmed
