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Vertebrate development depends on the formation of a closed circulatory loop consisting of intricate networks of veins, arteries, and lymphatic vessels. The coordinated participation of multiple molecules including growth factors, transcription factors, extracellular matrix proteins, and regulators of signaling such as small GTPases is essential for eliciting the desired cellular behaviors associated with vascular assembly and morphogenesis. We have recently demonstrated that a novel transcriptional pathway involving activation of the Epidermal Growth Factor-like Domain 7 (Egfl7) gene by the transcription factor CASTOR (CASZ1) is required for blood vessel assembly and lumen morphogenesis. Furthermore, this transcriptional network promotes RhoA expression and subsequent GTPase activity linking transcriptional regulation of endothelial gene expression to direct physiological outputs associated with Rho GTPase signaling, i.e., cell adhesion and cytoskeletal dynamics. Here we will discuss our studies with respect to our current understanding of the mechanisms underlying regulation of RhoA transcription, protein synthesis, and activity.
Baudino,
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression.
2002, Pubmed
Baudino,
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression.
2002,
Pubmed
Bellizzi,
RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease.
2008,
Pubmed
Bryan,
RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.
2010,
Pubmed
Carmeliet,
Molecular mechanisms and clinical applications of angiogenesis.
2011,
Pubmed
Carè,
MicroRNA-133 controls cardiac hypertrophy.
2007,
Pubmed
Chan,
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
2010,
Pubmed
Chappell,
Vascular development: genetic mechanisms and links to vascular disease.
2010,
Pubmed
Charpentier,
CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway.
2013,
Pubmed
,
Xenbase
Charpentier,
Transcriptional regulation of blood vessel formation: the role of the CASZ1/Egfl7/RhoA pathway.
2013,
Pubmed
Christine,
Vertebrate CASTOR is required for differentiation of cardiac precursor cells at the ventral midline.
2008,
Pubmed
,
Xenbase
Cui,
ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system.
1992,
Pubmed
Davis,
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.
1993,
Pubmed
Faried,
Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma.
2007,
Pubmed
Fitch,
Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells.
2004,
Pubmed
Fritz,
Rho GTPases are over-expressed in human tumors.
1999,
Pubmed
Geudens,
Coordinating cell behaviour during blood vessel formation.
2011,
Pubmed
Guettler,
RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding.
2008,
Pubmed
Heasman,
Mammalian Rho GTPases: new insights into their functions from in vivo studies.
2008,
Pubmed
Horiuchi,
Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.
2003,
Pubmed
Huveneers,
Adhesion signaling - crosstalk between integrins, Src and Rho.
2009,
Pubmed
Katoh,
Rho-associated kinase-dependent contraction of stress fibres and the organization of focal adhesions.
2011,
Pubmed
Kokai,
Myc regulates embryonic vascular permeability and remodeling.
2009,
Pubmed
Kong,
MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA.
2008,
Pubmed
Lawson,
Notch signaling is required for arterial-venous differentiation during embryonic vascular development.
2001,
Pubmed
Lelièvre,
VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases.
2008,
Pubmed
Liu,
Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation.
2006,
Pubmed
Liu,
miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
2011,
Pubmed
Liu,
CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression.
2011,
Pubmed
Lockman,
Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors.
2004,
Pubmed
Mellerick,
castor encodes a novel zinc finger protein required for the development of a subset of CNS neurons in Drosophila.
1992,
Pubmed
Mihira,
TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A.
2012,
Pubmed
Miralles,
Actin dynamics control SRF activity by regulation of its coactivator MAL.
2003,
Pubmed
Narumiya,
Use and properties of ROCK-specific inhibitor Y-27632.
2000,
Pubmed
Nichol,
Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7.
2010,
Pubmed
Nikolic,
EGFL7 ligates αvβ3 integrin to enhance vessel formation.
2013,
Pubmed
Parker,
The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation.
2004,
Pubmed
Patan,
Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling.
2000,
Pubmed
Patel-Hett,
Signal transduction in vasculogenesis and developmental angiogenesis.
2011,
Pubmed
Pillé,
Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.
2005,
Pubmed
Rodrigues,
A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular development.
2008,
Pubmed
,
Xenbase
Schmidt,
Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.
2009,
Pubmed
Shen,
Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.
2012,
Pubmed
Sivaraj,
G13 controls angiogenesis through regulation of VEGFR-2 expression.
2013,
Pubmed
Spindler,
Role of GTPases in control of microvascular permeability.
2010,
Pubmed
Takeuchi,
Blood pressure and hypertension are associated with 7 loci in the Japanese population.
2010,
Pubmed
Thompson,
Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells.
2002,
Pubmed
Valastyan,
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.
2009,
Pubmed
Valastyan,
Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis.
2009,
Pubmed
Wang,
Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway.
2013,
Pubmed
Xu,
Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.
2011,
Pubmed
,
Xenbase
